List of Contributors vii
Preface xi
1 Exploring and Exploiting Genetic Risk for Psychiatric Disorders 1
Gene Discovery
2 Delineating Additional Risk Factors 13
3 Data Collection: Next Steps in Psychiatric Genetics 39
4 Environmental Risk and Gene-Environment Relationships in Psychiatric Disorders 51
Understanding Rare Variation
5 Rare Variants: Shared Paths for Therapeutic Development and Neurobiological Investigation 69
6 Promises and Challenges of Precision Medicine in Rare Neurodevelopmental Disorders 103
7 Experimental Model Systems for Rare and Common Variants 117
Understanding Common Variation
8 Common Alleles: Next Steps in the Study of Common Variants 131
9 Hypotheses of How Common Variants Create Risk for Psychiatric Disorders 155
10 From Common Variant to Function: State-of-the-Art Approaches 167
11 Contextualizing Convergent Common Variant Mechanisms through Systems Biology 179
Clinical Considerations
12 Maximizing Near-Term Clinical Opportunities for Psychiatric Genetics 201
13 The Use of Polygenic Risk Scores in Clinical Psychiatry: Opportunities and Obstacles 219
14 Ethical Challenges Associated with Advances in Genetic Prediction of Neuropsychiatric Disorders 237
15 Psychiatric Genetic Counseling: Next Steps 249
16 Concluding Summary 261
Bibliography 267
Subject Index 319
Strungmann Forum Report Series 325
